ABiMed: An intelligent and visual clinical decision support system for medication reviews and polypharmacy management

ABiMed is a new system designed to help pharmacists and doctors work together to manage patients who take many medications. It makes the process easier and more efficient by automatically gathering patient information and presenting it in a clear way.

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This article and its accompanying video are automated summaries derived from ABiMed: An intelligent and visual clinical decision support system for medication reviews and polypharmacy management by Abdelmalek Mouazer, Romain Léguillon, Nada Boudegzdame, Thibaud Levrard, Yoann Le Bars, Christian Simon, Brigitte Séroussi, Julien Grosjean, Romain Lelong, Catherine Letord, Stéfan Darmoni, Matthieu Schuers, Karima Sedki, Sophie Dubois, Hector Falcoff, Rosy Tsopra, Jean-Baptiste Lamy. The original research was conducted solely by the paper's authors; PDFdigest did not conduct any of the research and makes no claims of ownership over the underlying scientific work.

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Key Takeaways
  1. 1 However, our aim is to be compatible with existing data flows and to encourage software publishers to endorse our approach.
  2. 2 On the contrary, the objective of this paper is to describe the ABiMed CDSS, including data exchange, ontological rule-based system, and original visual interfaces, and to focus on qualitative evaluations on the software aiming at testing how desirable are the functionalities we propose.
  3. 3 Pharmacists have to assess the interactions and adverse effects of 5-20 drugs, to identify inappropriate or missing drugs and to write the synthesis.
  4. 4 Clinical decision support systems (CDSSs) have been shown to be efficient in facilitating clinician work, increasing guidelines adherence, and improving healthcare .

Introduction

Elderly often receive polypharmacy, i.e. five drugs or more. Polypharmacy is both a public health, economic and ecologic issue.

Each new drug administered in polypharmacy increases the risk of adverse events by 12-18% .

The pharmacist assesses the treatment, and writes a synthesis with preconizations for the GP.

Important Note

Additionally, comments were added to a rule when the execution of the rule cannot be fully automatized.

Important Note

In future work, we would like to explore the use of argumentation as a way to structure communication between the pharmacist and the GP.

Research Question

On the contrary, the objective of this paper is to describe the ABiMed CDSS, including data exchange, ontological rule-based system, and original visual interfaces, and to focus on qualitative evaluations on the software aiming at testing how desirable are the functionalities we propose. However, our aim is to be compatible with existing data flows and to encourage software publishers to endorse our approach.

Methodology

However, few pharmacists are engaged in MR, because they lack the appropriate knowledge in geriatrics, they fear the reaction of GPs, and MR is a tedious task. This may turn MR as a more collaborative task, increasing the involvement of the GP.

Study Design

The prototype and its interfaces were presented, and participants’ opinions were collected.

ABiMed was presented during the workshop, and then the participants were divided in small groups and asked to use ABiMed themselves, for analyzing a clinical case.

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Results & Findings

Evidence shows it is a major problem in many countries, including Canada , Sweden and France . One solution for reducing polypharmacy is medication review (MR), “a structured interview with the patient, carried out by the pharmacist in collaboration with the general practitioner (GP) with the aim of optimizing patient care” .

  • Evidence shows it is a major problem in many countries, including Canada , Sweden and France .
  • One solution for reducing polypharmacy is medication review (MR), “a structured interview with the patient, carried out by the pharmacist in collaboration with the general practitioner.
  • Evidence shows that MR significantly reduces polypharmacy and saves money, without lowering the quality of care , and can save 273 C per patient-year .
  • MR may also have a positive ecological impact, by reducing the consumption of drugs .
  • Pharmacists have to assess the interactions and adverse effects of 5-20 drugs, to identify inappropriate or missing drugs and to write the synthesis.
Important Note

Many problems were: (1) of very low severity, e.g. the absence of handling of the “escape” key to close dialog boxes, (2) not directly related to the decision support activity, e.g. the absence of a “password lost” functionality, or (3).

Important Note

However, it requires temporal data, which may be difficult to obtain, especially for the pharmacist (e.g. when extracting drug treatment from health insurance reimbursement, only the drug delivered in the last months are present, thus the initial prescription date cannot.

Practical Applications

Other drugs may see their dose changed, and drugs may also be added, e.g. to control adverse events. For example, one may replace a drug involved in a serious interaction by another drug, involved in even more serious interactions.

The standard we selected may not be the most recent ones, but are the most used today in France.

To overcome this difficulty, it was made possible to exploit HeTOP’s inter-terminological semantic network by internally using more generic terminologies such as the controlled vocabulary thesaurus Medical Subject Headings (MeSH).

Important Note

While it might have been more obvious to work with an editor of pharmacy management software, the amount of clinical data available in such software is very limited.

Background

Polypharmacy, defined as the use of five or more medications, poses significant public health and economic challenges. Medication reviews conducted by pharmacists aim to optimize drug treatments and reduce unnecessary prescriptions. Despite the availability of clinical guidelines, the implementation of medication reviews remains limited due to the complexity and time required.

General principles

The system is built on principles that include intelligent implementation of clinical guidelines, automatic data extraction, comparative treatment analysis, and cooperative usage between healthcare professionals to enhance the medication review process.

Source Paper Figures and Captions

Source-paper figure
6 https://www.ema.europa.eu/en/documents/other/meddra-importantmedical-event-terms-list-version-260_en.xlsx Accessed 12 December 2023 7 https://www.academie-medecine.fr/effets-indesirables-des-medicamentschez-les-sujets-ages/ Accessed 12 December 2023
6 https://www.ema.europa.eu/en/documents/other/meddra-importantmedical-event-terms-list-version-260_en.xlsx Accessed 12 December 2023 7 https://www.academie-medecine.fr/effets-indesirables-des-medicamentschez-les-sujets-ages/ Accessed 12 December 2023
Source-paper figure
Figure 1: The flower glyph, showing the 13 adverse effect categories.
Figure 1: The flower glyph, showing the 13 adverse effect categories.
Source-paper figure
Figure 2: Architecture of the proposed CDSS.
Figure 2: Architecture of the proposed CDSS.
Source-paper figure
Figure 3: Screenshot of the adverse effect tab. The user preconized to deprescribe escitalopram, thus we are here in comparative mode.
Figure 3: Screenshot of the adverse effect tab. The user preconized to deprescribe escitalopram, thus we are here in comparative mode.
Source-paper figure
Figure 4: Screenshot of the interaction tab. The user clicked on the domperidone-escitalopram interaction.
Figure 4: Screenshot of the interaction tab. The user clicked on the domperidone-escitalopram interaction.
Source-paper figure
Figure 5: Dependencies between the various tabs of the CDSS and the categories of patient data. One way arrows indicate that the tab only reads the data. Two-way arrows indicate that it reads the data and can modify it (for the sake of presentation, the second arrow is shown next to the first one).
Figure 5: Dependencies between the various tabs of the CDSS and the categories of patient data. One way arrows indicate that the tab only reads the data. Two-way arrows indicate that it reads the data and can modify it (for the sake of presentation, the second arrow is shown next to the first one).
Source-paper figure
Figure 6: Opinion on the main tabs of ABiMed of the 12 GPs participating to the workshop.
Figure 6: Opinion on the main tabs of ABiMed of the 12 GPs participating to the workshop.
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Frequently Asked Questions

On the contrary, the objective of this paper is to describe the ABiMed CDSS, including data exchange, ontological rule-based system, and original visual interfaces, and to focus on qualitative evaluations on the software aiming at testing how desirable are the functionalities we.

However, few pharmacists are engaged in MR, because they lack the appropriate knowledge in geriatrics, they fear the reaction of GPs, and MR is a tedious task. ABiMed was presented during the workshop, and then the participants were divided in small groups.

Pharmacists have to assess the interactions and adverse effects of 5-20 drugs, to identify inappropriate or missing drugs and to write the synthesis. Clinical decision support systems (CDSSs) have been shown to be efficient in facilitating clinician work, increasing guidelines adherence, and.

To overcome this difficulty, it was made possible to exploit HeTOP’s inter-terminological semantic network by internally using more generic terminologies such as the controlled vocabulary thesaurus Medical Subject Headings (MeSH). When a checkbox is checked, a drop-down combo list appears, allowing to.

Many problems were: (1) of very low severity, e.g. the absence of handling of the “escape” key to close dialog boxes, (2) not directly related to the decision support activity, e.g. the absence of a “password lost” functionality, or (3) not problematic.

ABiMed is a new system designed to help pharmacists and doctors work together to manage patients who take many medications. It makes the process easier and more efficient by automatically gathering patient information and presenting it in a clear way.